Preparation and Evaluation of Glutaraldehyde Cross-Linked Chitosan Microspheres as a Gadolinium Reservoir for Neutron-Capture Therapy.
نویسندگان
چکیده
منابع مشابه
Are gadolinium contrast agents suitable for gadolinium neutron capture therapy?
OBJECTIVE Gadolinium neutron capture therapy (GdNCT) is a potential treatment for malignant tumors based on two steps: (1) injection of a tumor-specific (157)Gd compound; (2) tumor irradiation with thermal neutrons. The GdNC reaction can induce cell death provided that Gd is proximate to DNA. Here, we studied the nuclear uptake of Gd by glioblastoma (GBM) tumor cells after treatment with two Gd...
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157Gd is a potential agent for neutron capture cancer therapy (GdNCT). We directly observed the microdistribution of Gd in cultured human glioblastoma cells exposed to Gd-diethylenetriaminepentaacetic acid (Gd-DTPA). We demonstrated, with three independent techniques, that Gd-DTPA penetrates the plasma membrane, and we observed no deleterious effect on cell survival. A systematic microchemical ...
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This present study deals with synthesis, characterization and antibacterial activity of cross-linked chitosan-glutaraldehyde. Results from this study indicated that cross-linked chitosan-glutaraldehyde markedly inhibited the growth of antibiotic-resistant Burkholderia cepacia complex regardless of bacterial species and incubation time while bacterial growth was unaffected by solid chitosan. Fur...
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Determination of the relative biological effectiveness (RBE) of Auger electrons is a challenging task in radiobiology. In this study, we have estimated the RBE of internal conversion (IC) and Auger electrons released during Gadolinium neutron capture reaction (GNCR) by means of biological weighting functions (BWFs) with microdosimetric approach. Regarding the different distribution of Gadoliniu...
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The present study was undertaken to develop a suitable transdermal matrix patch of Metoprolol tartrate with different proportions of polyvinyl pyrrolidone (PVP) and chitosan crosslinked with glutaraldehyde (GA). The prepared transdermal patches were subjected to different physicochemical evaluations such as thickness, tensile strength, folding endurance, drug content, swellability, surface pH, ...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1998
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.46.537